EFFECT OF HESPERIDIN, A CITRUS FLAVONOID, ON GLUCOSE CONTROL AND INSULIN SENSITIVITY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS

Background and Aim: Although several studies have assessed the effects of different subclasses of flavonoids on glycemic markers, the evidence on the relationship of hesperidin and glycemic parameters has not been systematically assessed. Therefore, we performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the effectiveness of hesperidin supplementation in improving glycemic control.Methods: Electronic databases including PubMed, Web of science, Scopus, and Google Scholar were systematically searched up to May 2018. The risk of bias in individual studies was assessed using Cochrane collaboration’ tool. The random-effects model was used to calculate the weighted mean differences (WMDs) and 95% confidence intervals (CIs). Statistical heterogeneity was assessed by the Cochran s Q test and I2 statistic.Results: A total of 6 trials including 318 participants with 3 to 12 wk of duration were reviewed in the present meta-analysis. The results showed that hesperidin had no significant effect on levels of fasting blood glucose (WMD = -1.10 mg/dl; 95% CI: -3.79,1.57), insulin (WMD = -0.007 µU/ml; 95% CI: -1.20, 1.19), glycated hemoglobin A1c (WMD = -0.04 %; 95% CI: -0.14, 0.04), homeostasis model assessment for insulin resistance (HOMA-IR) (WMD = 0.117; 95% CI: -0.06, 0.29) and QUICKI (WMD = 0.135; 95% CI: -0.13, 0.39) with no significant between-study heterogeneity. Subgroup analyses also indicated that the effects were not affected by study design, study duration, or health status of the participants.Conclusion: Hesperidin supplementation has no beneficial effect on glycemic markers and so it cannot be recommended for improving glycemic control.

Keywords:

Hesperidin , Citrus Flavonoid , Glucose , Insulin , Meta-Analysis