THE EFFECTS OF CINNAMON POWDER SUPPLEMENTATION ON ADVANCED GLYCATION END PRODUCTS, AND ANTIOXIDANT STATUS IN TYPE 2 DIABETIC PATIENTS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Background and Aim: The aim of the current study was to determine the effect of a daily intake of three grams of cinnamon over eight weeks on advanced glycation end products, and antioxidant status in patients with type 2 diabetes. Methods: In a double-blind, randomized, placebo controlled clinical trial study, 44 patients with type 2 diabetes, aged 57 ± 8 years, were randomly assigned to take either a three g/day cinnamon supplement (n = 22) or a placebo (n = 22) for eight weeks. We measured the carboxymethyl lysine, total antioxidant capacity, and malondialdehyde levels at the beginning and the end of the study. Results: Thirty-nine patients (20 in the intervention group and 19 in the control group) completed the study. After an eight-week intervention, changes in the level of carboxymethyl lysine, total antioxidant capacity, and malondialdehyde were not significant in either group, nor were any significant differences between groups observed in inflammatory indicators at the end of the intervention. Conclusion: Our study revealed that cinnamon supplementation had no significant effects on inflammatory indicators in patients with type 2 diabetes.

Keywords:

type 2 diabetes , cinnamon , inflammatory indicators