THE EFFECTS OF MELISSA OFFICINALIS (LEMON BALM) IN CHRONIC STABLE ANGINA ON SERUM BIOMARKERS OF OXIDATIVE STRESS, INFLAMMATION AND LIPID PROFILE
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
INC15_645
تاریخ نمایه سازی: 30 دی 1397
Abstract:
Background and Aim: Coronary artery disease (CAD) is a major cause of death worldwide. Chronic stable angina (CSA) is the primary sign of CAD. Oxidative stress and inflammation play a substantial role in pathogenesis and progression of CAD. The aim of this study was to investigate the effects of oral administration of powdered Melissa officinalis (MO) on biomarkers of oxidative stress, inflammation, and lipid profile in patients with CSA.Methods: A randomized, double-blind, placebo-controlled clinical trial was performedin 80 patients with CSA. The subjects were randomly assigned to obtaineither oral MO 3 g/d (n=40) or placebo (n=40) for eight weeks. Anthropometric indices, biomarkers of oxidative stress, inflammation, and lipid profile were evaluated at baseline and post-intervention.Results: The mean serum concentrations of triglycerides, total-cholesterol, LDL-cholesterol, and malondialdehyde (MDA), and high sensitive C-Reactive Protein (hs-CRP) were lower in the intervention group compared with placebo (p<0.01) post intervention. Moreover, the mean serumconcentration of paraxonase 1 (PNO1) and HDL-c were higher (p<0.001) in the intervention group compared with the control group.Conclusion: Oral MO supplementation improves the lipid profile, MDA, hs-CRP, andPNO1 in patients with CSA.
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Authors
Ahmad Zare Javid
Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Assieh Mohammadzadeh
Department of Nutrition sciences, School of Para-medicine, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Habib Haybar
Atherosclerosis research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Maryam Ravanbakhsh
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran