EAT AND BE CURED: THE ROLE OF FOODS IN ANGIOGENESIS AS A NEW ERA IN FIGHTING CANCER

Cancer is one of the most terrifying disease in the world, which is globally; about 1 in 6 deaths is due to cancer. In last years, many factors have been addressed as preventative or treatment of cancer, which foods are one of the most important ones. Cancer cells needs foods and oxygen like other cells and oncogenic progression in solid tumors depends on development new vessels from existing vessels, particularly neoplasm growth, to provide element and nutrients as well as eliminate metabolic wastes. Several years’ struggles have been devoted to the development of anti-angiogenesis agents that were estimated to turn cancer into a chronic or latent disease with concrete clinical benefits. The purpose of the present article is to clarify role of foods as an anti-angiogenesis tool to defeat cancer.More than 120 novel antiangiogenic agents are in clinical, trials. Importantly, a growing body of preclinical, clinical and epidemiological data is demonstrating that angiogenesis inhibition can be applied for achieving cancer prevention. This is where your everyday diet comes into play. Eating to defeat cancer can be accomplished simply by adding a few of our cancer fighting angio foods to your meals each day. Like life itself, one’s diet is all about making choices. Since we all eat every day, why not choose foods that can reduce your risk of disease Several epidemiological studies have indicated that abundant consumption of foods from plant origin is associated with a compact risk of evolving several types of cancers. This chemo-preventive outcome is related to the high content of these foods in phytochemicals, such as polyphenols, that interfere with numerous procedures involved in cancer progression including tumor cell growth, survival and angiogenesis. In addition to the low consumption of plant-based foods, increased body mass and physical inactivity have recently emerged as other vital lifestyle factors influencing cancer risk, leading to the generation of low-grade chronic inflammatory conditions, which are a key process, involved in tumor progression. Several slight molecules present in the diet have been shown to have modulatory properties on angiogenesis. There is currently limited available information on the issue. Apart polyphenols, dietary protein also has an import role in this era as well. Several dietary proteins are able to modulate angiogenesis and that this fact opens new avenues for therapeutic interventions. Milk contains at least three proteins for which modulatory effects on angiogenesis including lactadherin, lactoferrin, Milk Angiogenin-2 are some of studies molecules. On the other hand, there is some scarce information on the potential of dietary lectins, edible plant proteins and high protein diets to modulate angiogenesis. Among the experienced polyphenols, apigenin and luteolin were the utmost potent angiogenesis inhibitors through their inhibitory effect on the inflammatory cytokine IL-6/STAT3 pathway. These effects resulted in modulation of the stimulation of extracellular signal-regulated kinase-1/2 signaling triggered by IL-6, as well as in a marked lessening in the proliferation, migration and morphogenic diversity of endothelial cells. Interestingly, these polyphenols also modulated the expression of IL-6 signal transducing receptor (IL-6Rα) and the secretion of the extracellular matrix-degrading enzyme MMP-2 as well as the expression of suppressor of cytokine signaling (SOCS3) protein. In summary, neoplasm development may be a essential target for cancer interference. Natural antiangiogenic molecules are present in varied dietary sources and represent a large spectrum of mechanisms, which will suppress the expansion of microscopic tumors. The management of vessel growth through dietary antiangiogenesis guarantees to redefine cancer as a illness which will be suppressed throughout a personality s lifespan, from infancy through adulthood.