APOA II GENOTYPES FREQUENCY AND THEIR INTERACTION WITH SATURATED FATTY ACIDS CONSUMPTION ON LIPID PROFILE OF PATIENTS WITH TYPE 2 DIABETES

Background and Aim: Several studies have suggested that APOA II-265T/C polymorphism affect lipid profile. The aim of this study was to investigate the effect of -265T/C APOA II polymorphism and saturated fatty acids(SFA) intake interaction on lipid profile in diabetic population who are at risk for lipid disordersMethods: In this cross sectional study, 697 type 2 diabetic patients participated. Food consumption data were collected using validated semi-quantitative FFQ during the last year. Realtime-PCR was used to determine APOA II -265T/C genotypes. The interaction between the genotypes and SFA intake with lipid profile was tested using analysis of covariance (ANCOVA).Results: According to APOA II -265T/C (rs5082) genotype distribution results, CC genotype with a frequency of 12.9% and TC with that of 47.7% showed the lowest and highest frequency in our population,respectively. CC genotype subjects had significantly lower total cholesterol, triglyceride, Cholesterol/HDLc ratio and non-HDL cholesterol than T allele carriers (p=0.009, p=0.02, p=0.02 and p=0.002, respectively). The interaction between genotype and SFA intake contributed to significant higher levels of LDL-c and LDL/HDL in CCs (p=0.05 and p=0.01), suggesting vulnerability of these individuals to high intake of SFA in the diet.Conclusion: APOA II polymorphism may influence the saturated fatty acid intake required to prevent dyslipidemia in the type 2 diabetic population

Keywords:

Apolipoprotein AII , Diabetes type 2 , Lipid profiles , Saturated fatty acid