Volumetric studies of acetaminophen in aqueous solution of ChCl / ethylene glycol deep eutectic solvent at T= (288.15to 318.15) K

One way to check the interactions between drug and solvent to find the best solvent inpharmaceutical fields is volumetric studies. The thermodynamic properties including volumetricproperties have been investigated using density measurements at T = (288.15 to 318.15 K) tounderstand the interactions between the components. The calculated thermodynamic parametersvalues confirm the strong solute – solvent interactions between acetaminophen and deep eutecticsolvent containing choline chloride as hydrogen bond acceptor and ethylene glycol as hydrogenbond donor (1:2) [1]. It seems that these types of green solvents are proper solvents rather thanionic liquids and organic solvents in pharmaceutical fields [2, 3].

Keywords:

Deep Eutectic Solvent , Volumetric Properties , Solubility , Acetaminophen , CholineChloride