The study of the salvation of paclitaxel in ionic liquids in the presence of biocompatible nano-particles using the molecular dynaimic simulation

Paclitaxel is an active agent against a broad types of tumor cells, including breast, ovarian, lung,head and neck cancers. A very strong anticancer agent produce from the Western yew tree [1].Here, we study the salvation of paclitaxel in ionic liquids by using the molecular dynamicsmethod by using NAMD package [2] and the visualizations were done by VMD.The studied ionic liquids include of methyl imidazoliumm, 1-methyl-3-methyl imidazoliummand 1-Ethyl-3-methyl imidazoliumm and chloride ion as anion. The paclitaxel and ionic liquidcomplex box dimensions was 120 Å and contains 1500 number of atoms. The system is contain1 paclitaxel and 5 paclitaxel in each box. The liquid ions are made of [MIM][Cl] and[MMIM][Cl].