Measurement and Modeling the Volumetric Properties of Aqueous Solutions of Guaifenesin Drug in the Presence of NaCl

Guaifenesin(GG), also known as guaiphenesin or glyceryl guaiacolate, isan expectorant medication sold over the counter and usually taken by mouth to assist thebringing up (expectoration) of phlegm from the airways in acute respiratory tract infections[1].Study on the thermodynamic and physicochemical properties of each component of medicinesbefore the complexity of the systems can provide useful informations[2]. Therefore, in this work,density data of GG drug in water and aqueous solutions of NaCl have been measured withinNaCl molality range of (0.05, 0.1, and 0.15) mol kg-1 at T = (298.15, 308.15 and 318.15) K. Theapparent molar volume (  V ) have been calculated from density values with equation of(...); in which m is molality of solution, M is the molar mass of the GG drug, d andd0 are densities of solution and solvent, respectively. The behaviours of apparent molar volumefor aqueous solution of GG and also GG + NaCl indicates a decrease in the interaction of GGH2O,as well as GG-NaCl-H2O with temperature increasing. The V values for the aqueoussolutions containing drug and NaCl are higher than those of the aqueous solutions containing thedrug and increase with increasing the concentration of salt. This behaviour suggests that the sizeof the GG molecule increases due to the decrease in the interaction of GG with water in thepresence of salt. The apparent molar volume values of the considered solutions have successfullybeen modelled via the Redlich–Meyer type equation[3] in the dilute region.

Keywords:

Volumetric Properties , Aqueous Solutions , Guaifenesin Drug , NaCl