Evaluation of UNIFAC Model in Predicting of Naproxen Solubility in Some Aqueous Solutions of Choline Chloride Based Deep Eutectic Solvent

Prediction of drugs solubility in various solvents is one of the main challenges in drugdiscovery and advanced investigation. The thermodynamic models are fast, reliable, and costeffectivemethods to select the best solvent or solvent mixtures to increase drug solubility.Experimental solubility determination is not always possible because of the small amount ofproduct available in the early stages of a drug development. In addition, deep eutectic solventsare neoteric green solvents. They have advantages such as a lower cost and desirableenvironmental impact, they are liquid at room temperatures typically formed by mixing two solidcompounds, such as a quaternary ammonium salt as hydrogen bond acceptor (HBA) (e.g. cholinechloride) and a hydrogen bond donor (HBD) (e.g. urea or a carboxylic acid) at their eutecticcomposition with melting point much lower than that of the individual components[1, 2]. In thispaper, UNIFAC activity coefficient model[3] is tested for prediction of naproxen (NAP) solubilityin choline chloride based deep eutectic solvents and the performance of this model is comparedwith experimental data.

Keywords:

Deep Eutectic Solvent , Solubility , Naproxen , Choline Chloride , UNIFAC Model