Ghazaleh Sankanian - Hematopoeitic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zahra Momeni - Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Hossein Kazemi - Department of Immunology, Iran University of Medical Sciences, Tehran, Iran
Elham Roshandel - Hematopoeitic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Background and Aim: Class I human leukocyte antigens (HLAs) have an important role in many kinds of transplantation specially allogeneichematopoietic stem cell transplantation (aHSCT) in which all majorHLA-I members (HLA-A, -B, -C) must be matched between the donorand recipients. Due to the cost, routine HLA-typing is low resolutionand despite the donor-recipient fully matched HLA-I, some post-aHSCTcomplication such as graft-versus-host disease might occur. In this study,we investigated the question that whether any matched HLA-I membershas an association with GvHD.Methods: In this retrospective study, the data of low-resolution HLA-Ityping of 190 patients who underwent aHSCT as well as their GvHDstatus were obtained from their clinical records. All patients receivedHLA-A, -B, -C fully matched hematopoietic stem cells. The associationbetween the types of HLA-I with GvHD status of patients were analyzedusing multivariate analysis.Results: Among the patients, only the patients with donor-recipientmatched HLA-A*01 have significantly high rate of acute GvHD (aGvHD)(P value= 0.048, RR=1.31) and significantly mortality rate (P value=0.04, RR= 1.21). Other donor-recipient matched class-I HLAs have nosignificant association with aGvHD and mortality. None of HLA-I have asignificant association with chronic GvHD.Conclusion: In accordance with the results, It seems that the HLA-Amight be more important in post-aHSCT complications especially lifethreateningaGvHD and should be typed with high-resolution methods.

Human leukocyte antigen; HLA-I; GvHD; Mortality