Design and Fabrication of Injectable Hyaluronic Acid Hydrogels by Guest−Host Assembling

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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NSCMRMED03_358

تاریخ نمایه سازی: 30 دی 1397

Abstract:

Background and Aim: Injectable hydrogels afford direct injection orcatheter delivery to tissues. However, many injectable hydrogels requirelong reassembly times or the use of triggers such as chemical initiatorsor heat.Methods: We developed an injectable hyaluronic acid (HA) hydrogelbased on the guest−host interactions of adamantine modified HA (guestmacromer, Ad-HA) and β-cyclodextrin modified HA (host macromer,CD-HA).Results: The ability of conjugation to HA was confirmed by 1H NMRspectroscopy. Mixing of Ad-HA and CD-HA resulted in rapid formationof a hydrogel composed of guest−host bonds.Conclusion: The guest−host assembly mechanism allowed both shearthinningbehavior for ease of injection and near instantaneous reassemblyfor material retention at the target site. These hydrogels show potential asa minimally invasive injectable hydrogel for biomedical applications andtissue engineering.

Authors

Samaneh Soltani

Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran

Rahmatollah Emadi

Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran

Shaghayegh Haghjoo Javanmard

Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

Mahshid Kharaziha

Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran