Synthesis of (Fe3O4 /SiO2) nano – particles sorbents modified with surfactant for extraction of medical samples

In this study , a new type of superparamagnetic silica-coated ( Fe3O4/SiO2 core/shell ) nano - particles modified by the surfactant sodium dodecyl sulfate (SDS) has been successfully synthesized and applied for extraction of Pyridostigmine bromide and Neostigmine methyl sulfate from medical sample based on mixed hemimicelles solid-phase extraction(MHSPE). Compared with pure magnetic particles, a thin silica layer would protect the iron oxide core from leaching out in acidic conditions [1]. SDS –coated Fe3O4/SiO2 NPs system was selected due to lower elution volume required and more effective of the target compounds [2]. The advantage of this new method still include easy preparation and regeneration of sorbents, short times of sample pretreatment and high extraction yield. A formation of superparamagnetic silica- coated (Fe3O4 /SiO2 core/shell) nano- Particles inspected by using scanning electron microscopy (SEM) and x-ray diffraction (XRD). Under selected conditions, concentration factor of 143 was achieved by using this method to extract 500 mL of different matrices. The detection limits obtained for PB and NEO with UV spectrophotometer was 30.7 and 31.16 ng/mL.