Impact of exercise endurance training on pur gene expression and cardiac function

Introduction: Endurance training has significant effects on the renewal of heart tissue, including myosin heavy chain (MHC) proteins. On theother side, Purine-rich element-binding protein β (pur ) decreases the αMHC gene expression. The aim of this study was to determine theimpact of exercise endurance training on pur gene expression in the heart of Wistar rats.Methods: Fourteen rats have been kept under controlled conditions and after familiarizing with training protocol, they were divided intocontrol groups and experimental groups. The experimental group performed a 10-week treadmill running program for 30 min/day, 5days/week. 48 hours after the last training session, the rats were anesthetized and the heart and their left ventricle were taken out and purexpression was measured using real time PCR method. All data were analyzed using t test.Results: In this study, the results of M-mode echocardiography showed that endurance training led to cardiac hypertrophy. After endurancetraining, the heart weight, especially the left ventricular weight significantly increased. The pur gene expression significantly decreased in theleft ventricular tissue of endurance-trained rats.Conclusion: The results of this study revealed that endurance training has considerable effects on heart size and pur gene expression. Thepur gene also repressed MHC gene expression; it seems that the changes in heart structure related to MHC gene expression.

Keywords:

Gene expression , pur gene , Cardiac plasticity , Endurance training