Research Paper: Celecoxib or Prednisolone for Treatment of Medication Overuse Headache: A Randomized, Double-Blind Clinical Trial in Migrainous Patients

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_CJNS-4-12_003

تاریخ نمایه سازی: 18 اسفند 1397

Abstract:

Background:Treatment of Medication Overuse Headache (MOH) is yet under debate and Celecoxibas a Cyclooxygenase 2 (COX2) -inhibitor has not been tried widely as a pain relief drug for this typeof headaches in migrainous patients.Objectives: comparing the efficacy of celecoxib versus prednisolone for withdrawal period of MOH.Materials & Methods: A double-blind, randomized clinical trial was carried out, on 75 patientswith MOH who visited the Isfahan Neurology Clinic in 2016. They were assigned into two groups oforal prednisolone and celecoxib prescribed for 15 days. Any changes in the duration (average hoursof daily headache), frequency, and severity of headaches, and intake of rescue medication and theirside effects were recorded after the 15-day intervention period. Data were analyzed by independent t,paired t, Mann-Whitney, Wilcoxon test, and chi-square tests in SPSS software version 20.Results: Average duration of headache in both groups significantly decreased after treatment(P<0.001). It decreased significantly in celecoxib group (P=0.04). Headache frequency decreasedmore but not significantly in the celecoxib group (P=0.08). Considering MIGSEV (MigraineSeverity) and VAS (Visual Analogue Scale) scales, headache severity alleviated significantly aftertreatment in both groups (P<0.001). The decrease was more noticeable in the celecoxib group. Needfor rescue medications (P=0.048), and side effect appearance (P=0.001) was also lower in patientswho took celecoxib, compared to the other group.Conclusion: Celecoxib showed higher efficacy and fewer side effects, compared to prednisolone intreatment of medication overuse headache in migrainous patients.

Authors

Ahmad Chitsaz

Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammadreza Najafi

Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Maryam Shirmardi

Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Roshanak Mehdipour

Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran