Designing and Synthesis of Novel Coumarin Derivatives as Qourum Sensing Inhibitors

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

CBGCONF05_180

تاریخ نمایه سازی: 3 اردیبهشت 1398

Abstract:

Quorum sensing (QS) is a process of cell-to-cell communication through signaling molecules coined autoinducers. In gram-negative bacteria acyl homoserine lactones act as autoinducer molecules. Bacteria use QS to regulate gene expression such as biofilm formation. Biofilms are multicellular communities held together by self-produced extracellular polymeric substances. They are major problem in industry, humanhealth, etc. Many efforts have been employed to control or eliminate biofilms. Pseudomonas aeruginosa is a well-known gram-negative bacterium that forms biofilms and produces virulence factors via quorum sensing. In the present work, we have Designed and Synthesized novel coumarin derivatives which could act as Quorum Sensing inhibitors; these compounds contain different alkyl groups. The chemical structures of synthetic compounds were verified by H-NMR, C-NMR and FT-IR spectroscopy. To biologically examine theeffects of coumarin analogues, bacteria cell (Pseudomonas aeruginosa) were grown on L-B agar to form biofilm in 48 hours, along with addition of synthetic compounds. The results indicated that one of alkylated coumarin analogues inhibited biofilm, more effective the original coumarin compound. To better quantify the inhibition of the synthetic compound, IC50 (Inhibitory concentration) will be measured.

Authors

Hamid R. Kalhor

Biochemistry research laboratory, Department of chemistry, Sharif University of Technology, Tehran, Iran

Sirwan Mansoori

Biochemistry research laboratory, Department of chemistry, sharif university of technology, Tehran, Iran