Association of single nucleotide polymorphism rs6983267 with esophageal cancer grades

Introduction: Esophageal cancer is the sixth causes of cancer-related death worldwide. Recentgenome-wide association studies have identified single-nucleotide polymorphisms (SNPs) whichmight be effective in increasing the risk of different cancers. Some of these studies havedemonstrated strong evidence for associations of various genetic variants such as rs6983267 onchromosome 8q24 with susceptibility to prostate, colorectal, breast, bladder, ovarian, thyroid andsome other cancers in different populations. Therefore, rs6983267 can be good candidate as amulticancer susceptibility marker. This polymorphism is G/T single nucleotide variation. It hasbeen reported that individuals with the GG genotype of rs6983267 are more likely to develop thementioned cancers.Materials Methods: In the current study to determine the relationship between the threegenotypes of rs6983267 and grades of esophageal cancer, we analyzed these variants in 110esophageal cancer patients in Mashhad, Iran. Genomic DNA was extracted from ml blood and thers6983267 SNP was genotyped using Taqman real time PCR method.Results: The Chi-square test was used to compare the association between genotypes of rs6983267and grades of cancer. Significant differences were observed between various genotypes and the grades of tumors. Our results indicated that patients with higher grades of tumors were mostlygenotyped with allele.Conclusion: In conclusion, our findings suggest that different genotypes of rs6983267 SNP havesignificant association with grades of esophageal cancer. However, larger populations in furtherstudies are required to confirm the association between the risk allele of and higher grades ofesophageal cancer