One-pot synthesis of isoxazole-5(4H)-ones via three-component condensation of β-keto esters, hydroxylamine hydrochloride, and substituted benzaldehydes in the presence of iodine in water
Publish place: Fourth National Conference on Materials Engineering, Chemical Engineering and Industrial Safety
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
MCIS04_012
تاریخ نمایه سازی: 10 اردیبهشت 1398
Abstract:
In the present work, highly efficient method for the synthesis of 3-substituted-4-arylmethylidene-isoxazol- 5(4H)-one heterocyclic compounds by the three-component reaction between substituted benzaldehydes, β-keto esters, and hydroxylamine hydrochloride under the influence by iodine as commercially available, inexpensive, and easy to handle catalyst has been described. The benefits of this method are good yields, relatively shorter reaction times, simplicity of implementation, using water as the solvent, and respect of the environment.
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Authors
Hanieh Ostadzadeha
School of Chemistry, Damghan University,
Hamzeh Kiyania
School of Chemistry, Damghan University,