Hanieh Ostadzadeha - School of Chemistry, Damghan University,
Hamzeh Kiyania - School of Chemistry, Damghan University,

In the present work, highly efficient method for the synthesis of 3-substituted-4-arylmethylidene-isoxazol- 5(4H)-one heterocyclic compounds by the three-component reaction between substituted benzaldehydes, β-keto esters, and hydroxylamine hydrochloride under the influence by iodine as commercially available, inexpensive, and easy to handle catalyst has been described. The benefits of this method are good yields, relatively shorter reaction times, simplicity of implementation, using water as the solvent, and respect of the environment.

Aqueous media, Iodine, 3-Substituted-4-arylmethylidene-isoxazol-5(4H)-one, Three-component, Greensynthesis.