Isolation of antimicrobial compounds producing actinobacteria from the shore soil of Lake Urmia

In recent years, the emergence of multi-drug resistant bacteria has caused many problems for patients, clinical settings, and human societies. Therefore finding a newsource of effective antimicrobial agents is inevitable. At the present, the marine microorganisms, especially actinobacteria, have been considered as potential sources of antimicrobials compounds. Also, extreme ecosystems are untapped sources of microorganisms with the ability to produce new biological compounds. At the present study,the shore soil of Lake Urmia (which is a hypersaline lake) was investigated to find out antimicrobial compounds producing bacteria. In order to demonstrate the production of antimicrobial compounds, isolated bacteria were exposed to pathogenic bacteria and the inhibition zone was investigated. The results showed one isolate had antimicrobial activity against pathogenic bacteria. According to morphological characteristics and sequence of the 16s rRNA gene, this isolate was identified as Streptomyces. The results of this study revealed bacteria from shore soil of Lake Urmia could be potential sources of antimicrobials and even other new biological compounds. Further studies are needed to purify and identify the chemical properties of the produced antimicrobial compounds

Keywords:

Antimicrobial compounds , Actinobacteria , Lake Urmia