Anti-proliferative effects of the nano-oxalipalladium complex in comparison with oxalipalladium against human colon cancer cell line of HCT116

Platinum (II) complexes are widely used in the treatment of several human malignant diseases, such as colon cancer. Previous reports have represented several disadvantages of cis-platin particularly related to general toxicity which leads to undesirable side effects and to drug resistance phenomena limit its clinical application. Recently, Pd(II) analogues were considered as anti-tumor drugs due to its structural similarities between Pd and Pt, as well as low toxicity. So, in the present study, we have investigated the anti-cancer activity and death induce ability of a newly synthesized nano-oxali-palladium using ginger extract and free oxali palladium by (MTT) assay after 24 and 48 hours incubation times. The 50% cytotoxic concentrations (Cc50) of nano-oxali-palladium were determined 32.5 and 18 μM after 24 and 48 hours incubation times, respectively. On the other hand, this value was evaluated 600 and 433 μM for free oxali-palladium after 24 and 48 h incubation times. Also, 13 and 18 mg/ml of ginger extract after 24 and 48 hours incubation times, were induced 50% death in HCT116 colon cancer cell line. Above results show that the newly synthesized nano-oxali-palladium using ginger extract has a more cytotoxic effect on colon cancer cell line after 24 and 48 h incubation times. Also, the anticancer activity of ginger extracts used in nanooxali-palladium increases the cytotoxicity of this compound

Keywords:

Green chemistry , Ginger extract , Nano-oxalipalladium , Colon cancer