Evaluation of Zinc level in the serum of hypo and hyperthyroidism patients in Urmia County

Zinc plays a crucial role in biochemical reactions and the immune system, and it is an important part of metalloenzyme, translation factors, and other proteins. Elemental Zinc is involved in several functions in organs including endocrine regulation and secretion, thyroid hormones and Insulin. This element is required for the accurate function of 5 Iodotyrosine deiodinase type 1 for conversion of thyroxine (T4) to active triiodothyronine (T3) and triiodothyroninereceptors for biological activity. In this cross-sectional study, 120 patients were randomly entered to the study. The patients, 43 male and 77 female average age of 38 ±16, were randomly divided into hypothyroid group, hyperthyroid and control groups (n=40).3 mL venous blood sample was taken and after serum division, hormone levels of T3, T4, TSH and elemental zinc were analyzed by ELISA and chemical methods, respectively . Statistical analyses were performed using SPSS Version 22. Normalization of data was performed using Kolmogorov-Smirnov and Tukey’s test and the level of significance was set (p<0.05). The findings of the present study showed that in the hypothyroid group there was a significant increase in TSHserum level (P<0.001) and a significant decrease in serum levels of T4 and zinc (P<0.001). No significant difference was observed in serum level of T3. In the hyperthyroidgroup, there was a significant increase in TSH serum level (P<0.001) and a significant increase in serum levels of T4 and zinc (P<0.005).No significant difference was observed in serum level of zinc. This study showed parallel results with other researchers who showed there was significant decrease in hypothyroid patients zinc value in comparison with the controlgroup. One of the explanations for these results is that zinc absorption in hypothyroid patients is disrupted and zinc deficiency causes disorders in 5 Iodotyrosin deiodinase type ı activity and deiodination of thyroxine to triiodothyronine. In this study zinc level of hyperthyroidism, patients did not show the significant change that was in agreement with the results of other researchers which reported a significant increase. Zinc levels in hypothyroidism and hyperthyroidism showed no significant changes. This was in agreement with the results of others. It seems that elemental zinc supplementation may improve the function of the thyroid gland in hypothyroid patients

Keywords:

Hypothyroid , Hyperthyroid , Tiroxin , Triiodothyronine , Zinc