The structural changes of hormone Human Chorionic Gonadotropin (hCG) in Ultrasound exposure

The hormone human chorionic gonadotropin (better known as hCG) is a glycoprotein produced during pregnancy. It is made by cells formed in the placenta.Identifying the various effects of noise pollution on physiological characteristics of living organisms in order to help reduce its effects must be taken seriously. So, in this research, the structural changes of hCG in ultrasound exposure was studied with UV-Visible spectroscopy, Fluorescence spectroscopy and Fouriertransform infrared spectroscopy (FTIR). The hyperchromic in UV-Vis and a clear increase in the Trp fluorescence suggest that the protein structure changed after 30 min ultrasound exposureand unfolded. Furthermore, the FTIR studies evaluated the changes in bending and stretching bonds of functional groups of the hormone. Furthermore, the secondary structure of hCG changed and a transition from α-helix to β-structure after 30 min ultrasoundappeared. According to the findings of this study, it seems that sound pollution threats the health of pregnant women and fetus. Consequently, it is recommended to present necessary training about the hazardous effects of sound pollution on the pregnancy of women residing in crowded areas of the city and also to adopt ways to diminish this pollution

Keywords:

Human Chorionic Gonadotropin (hCG) , Ultrasound , UV-Visible spectroscopy , Fluorescence spectroscopy , Fourier-transform infrared spectroscopy (FTIR)