Zinat Gordi - Department of Chemistry, Payame Noor University, Tehran, Iran
Ali Rajaee - Department of Chemistry, Payame Noor University, Tehran, Iran
Ebrahim Fooladi - Department of Food Nanotechnology, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran

2-aminothiazoles are very important heterocyclic compounds in medicinal chemistry and applied as a ligand in estrogen receptor [1]. In the recent years, application of modified magnetic nanoparticle (Fe3O4) as a reusable and highly stable magnetic nanoparticle has attracted much attention in 2-aminothiazole synthesis [2]. Among many materials, graphene and its derivatives are considered potential materials for the immobilization of nanoparticles. In the present study, Fe3O4/GO/TiO2 nanocomposite was prepared by a sol-gel method for titania coating on Fe3O4/GO. The Fe3O4/GO/TiO2 composite particles were characterized by FT-IR and TEM. In this reaction thiourea was reacted with various α-bromo Acetophenones in the presence of (Fe3O4/GO/TiO2) catalyst affording the desired 2-aminothiazoles in high yields. In conclusion, we have successfully demonstrate for the first time that Fe3O4/GO/TiO2 composite could be used as an efficient solid recyclable magnetic nanocatalyst for convenient synthesis of 2-aminothiazole derivatives under mild conditions. The novelty and synthetic volubility of this method developed the mild reaction conditions, easy experimental procedure, avoiding the use of organic solvents and recovery of the magnetic nanocatalyst.