Synthesis of the Cu (II) Schiff base complexes supported on alumina nanoparticle; for preparation of 5-Substituted-1h-tetrazoles derivatives

Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Many Schiff base complexes show excellent catalytic activity in various reactions and in the presence of moisture[1]. Complexes of Schiff bases have been used as antibacterial, antifungal, anticancer, antitubercular, hypertensive, and hypothermic agents[2]. Tetrazoles are an important class of heterocyclic nitrogen-rich compounds, due to their wide range of applications in agriculture, pharmacy, medicine, chemistry and material science, So the preparation of various tetrazole derivatives over the past few years has been developed rapidly.In pharmacy, they are employed as antidiabetics, antibiotics and HIV-inhibitor Owing to lower toxicity and higher lipophilicity of tetrazoles, they can be used as isosteric replacements in drugs Furthermore, they are applied as ligands in coordination chemistry [3]. In this research, the Cu (II) Schiff base complexes supported on alumina nanoparticle were used for the preparation of 5-Substituted-1h-tetrazoles. In this case (1/5mmol) NaN3 (1/5mmol) NH2OH.HCl were treated with (1mmol) benzaldehyde derivatives through one-pot method in green solvent at short times and very good yields (Scheme1).