Sensitive determination of imatinib in human biological samples by differential pulse voltammetry based on carbon paste electrode modified by MMWCNTs/PAN NFs

In the present work, the electrochemical oxidation of new generation of anti-cancer drug, imatinib, using by differential pulse voltammetry based on carbon paste electrode modified by MMWCNTs/PAN NFs (MMWCNTs/PAN NFs/CPE) has been reported. The results of a study showed that imatinib provided well-shaped oxidation peak at positive potential of +0.8 V (vs .EAg/AgCl) in the phosphate buffer solution at pH 6.0. The experimental conditions, i.e. pH, modulation amplitude, a modulation time, a step potential, and a scan rate, were optimized, A simple, rapid, selective and sensitive DPV procedure for the determination of imatinib was performed in the concentration range of 1.69 × 10-9 - 4.24 ×10-7 mol/L with the limit of detection (LOD) and the limit of quantification (LOQ) of 3.2×10-10 and 1.8×10-9, respectively.The proposed method with using anodic signal of imatinib at MWCNT/CPE shown comparable detection limit as for boron-doped diamond electrode and hanging mercury drop electrode in the determination of this anticancer drug [1, 2].