Sensitive determination of imatinib in human biological samples by differential pulse voltammetry based on carbon paste electrode modified by MMWCNTs/PAN NFs
Publish place: 20th Iranian Chemical Congress
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IRANCC20_108
تاریخ نمایه سازی: 28 اردیبهشت 1398
Abstract:
In the present work, the electrochemical oxidation of new generation of anti-cancer drug, imatinib, using by differential pulse voltammetry based on carbon paste electrode modified by MMWCNTs/PAN NFs (MMWCNTs/PAN NFs/CPE) has been reported. The results of a study showed that imatinib provided well-shaped oxidation peak at positive potential of +0.8 V (vs .EAg/AgCl) in the phosphate buffer solution at pH 6.0. The experimental conditions, i.e. pH, modulation amplitude, a modulation time, a step potential, and a scan rate, were optimized, A simple, rapid, selective and sensitive DPV procedure for the determination of imatinib was performed in the concentration range of 1.69 × 10-9 - 4.24 ×10-7 mol/L with the limit of detection (LOD) and the limit of quantification (LOQ) of 3.2×10-10 and 1.8×10-9, respectively.The proposed method with using anodic signal of imatinib at MWCNT/CPE shown comparable detection limit as for boron-doped diamond electrode and hanging mercury drop electrode in the determination of this anticancer drug [1, 2].
Authors
Masoud Ghapanvari
Faculty of Chemistry, Bu Ali Sina University, Hamedan, Iran
Tayyebeh Madrakian
Faculty of Chemistry, Bu Ali Sina University, Hamedan, Iran
Abbas Afkhami
Faculty of Chemistry, Bu Ali Sina University, Hamedan, Iran