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Title

The synthesis of 4,4´-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s using boric acid aqueous solution system

Year: 1397
COI: IRANCC20_119
Language: EnglishView: 167
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Authors

Ahmad Reza Moosavi-Zare - Sayyed Jamaleddin Asadabadi University, Asadabad, ۶۵۴۱۸۳۵۵۸۳, I. R. Iran.
Hamid Goudarziafshar - Sayyed Jamaleddin Asadabadi University, Asadabad, ۶۵۴۱۸۳۵۵۸۳, I. R. Iran.
Hadis Afshar-Hezarkhani - Sayyed Jamaleddin Asadabadi University, Asadabad, ۶۵۴۱۸۳۵۵۸۳, I. R. Iran.
Mohammad Rezaei-Gohar - Sayyed Jamaleddin Asadabadi University, Asadabad, ۶۵۴۱۸۳۵۵۸۳, I. R. Iran.

Abstract:

Bis(pyrazolyl)methanes (BPMs) including 4,4´-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s have a broad spectrum of approved biological activity, being usedas anti-inflammatory, antipyretic, gastric secretion stimulatory, antidepressant, antibacterial, and antifilarial agents [1]. 4,4´-(arylmethylene)-bis(3-methyl-1-phenyl- 1H-pyrazol-5-ol)s, were prepared by various methods including application of piperidine in ethanolic solution [2], tandem Knoevenagel-Michael reaction in benzene solutions [3], application of sodium dodecyl sulfate in aqueous media [4], and electrocatalytic synthesis [5]. Having above facts, we have reported the preparation of bis(pyrazolyl)methanes by the condensation reaction of phenylhydrazine, ethyl acetoacetate and aryl aldehydes in the presence of boric acid, at 70 °C under aqueous conditions as a mild and green reaction condition (Scheme 1).

Paper COI Code

This Paper COI Code is IRANCC20_119. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/850755/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Moosavi-Zare, Ahmad Reza and Goudarziafshar, Hamid and Afshar-Hezarkhani, Hadis and Rezaei-Gohar, Mohammad,1397,The synthesis of 4,4´-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s using boric acid aqueous solution system,20th Iranian Chemical Congress,Davarzan,https://civilica.com/doc/850755

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