Synthesis of 2-substituted Perimidine Derivatives using Nanosawdust/ TiCl4 as a Green Catalyst under Solvent-free Condition

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

IRANCC20_131

تاریخ نمایه سازی: 28 اردیبهشت 1398

Abstract:

Perimidines are a kind of heterocycles containing a dihydropyrimidine ring and peri-fused to the naphthalene structure [1]. Multinuclear N-heterocyclic compounds, such asperimidines, are of wide interest because they exhibit a diverse range of biological activities. Among their multiple applications in pharmaceutics, including also activity asantiulcer, antifungal, antimicrobial, immunosuppres- sive agents and enzyme inhibitors, a particular interest is assumed by the established chemotherapeutic, anti-cancer and antiproliferative properties of perimidine derivatives [2]. The most commonly method for the preparation of perimidines is the condensation reaction of 1, 8-diaminonaphthalene with a carbonyl group, which requires a special reagent or force reaction conditions [3]. Many procedures for the synthesis of dihydroperimidines have been reported in the presence of various catalysts. Herein, we wish report the synthesis of dihydroperimidines using various aromatic aldehydes and 1,8- diaminonaphthalene in the presence of nanosawdust/TiCl4 as a green catalyst under solvent-free conditions (Scheme1).The advantages of this work are simple work-up, mild condition, short reaction time and high yields.

Authors

Abdolhamid Bamoniri

Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I. R.Iran

Maedeh Dastmard

Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I. R.Iran