Zohreh Ghadamyari - Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
Ali Shiri, - Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
Seyed Mohammad Seyedi - Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
Amir Khojastehnezhad - Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Multicomponent reactions (MCRs) have become current research interest to the synthetic organic chemist owing to their synthetic efficiency, atom economy and procedural simplicity [1]. MCRs are also an important tool to the modern drug development research so as to achieve a synthetic target in an expeditious way [2]. In this study a new zirconium-purphirine was immobilized on the edge of graphene oxide via covalent bond and the its catalytic activity has been tested in synthesis of 3,4-dihydropyrimidine-2-one via Biginelly reaction. The structure of catalyst was characterized with different techniques (TEM, SEM, FT-IR, TGA, EDX, XRD, ICP and Raman). According to FT-IR, SEM, TEM, EDS, TGA, XRD and Raman techniques, the structure of the catalyst has been approved and successful immobilization of Metal-Organic-Framework has been confirmed. Also ICP analysis shows that, the amount of zirconium is about 2 percent. This reaction was carried out from the reaction of aromatic and aliphatic aldehyde, ethylacetoacetate and urea in presence of catalytic amount of prepared catalyst. The catalyst could proceed the reaction in short reaction time and good to excellent yields. The reusability of the prepared nanocatalyst was examined five times with only a very slight loss of its catalytic activity.

Graphene Oxide; Metal-Organic-Framework, Biginelly Reaction, 3,4-dihydropyrimidine-2-one