Green Synthesis of Pyrano[2,3-c]pyrazoles and Spiro[indoline-3,4ˊ- pyrano[2,3-c]pyrazoles] Using Nano-silica Supported 1,4- Diazabicyclo[2.2.2]octane as a Novel Catalyst
Publish place: 20th Iranian Chemical Congress
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IRANCC20_151
تاریخ نمایه سازی: 28 اردیبهشت 1398
Abstract:
Pyrano[2,3-c]pyrazoles have attracted considerable interest in organic synthesis because of their wide application in medicinal and pharmaceutical chemistry [1]. In addition, spirooxindoles are unique core structures found in pharmaceuticals [2] and natural products such as Spirotryprostatin (A & B), Pteropodine, Marcfortine B and Glesemine [3].In this research, nano-silica supported 1,4-diazabicyclo[2.2.2]octane (nano-SiO2/DABCO) as a novel heterogeneous catalyst was prepared and fully characterized by FT-IR, FESEM, TEM, EDX, TGA/DTA, XRD, BET and elemental (CHN) analysis. This basic nanocatalyst was successfully applied for synthesis of pyrano[2,3-c]pyrazole and spiro-2-oxindole derivatives via a one-pot four-component reaction at ambient temperature.Simplicity, easy work-up, high to excellent yields, short reaction times, ease of recovery of the catalyst and green nature of this protocol make it appealing.
Authors
Bi Bi Fatameh Mirjalili
Department of Chemistry, Faculty of Sciences, Yazd University, Yazd, Iran
Naeimeh Salehi
Department of Chemistry, Faculty of Sciences, Yazd University, Yazd, Iran