Electrospun Poly ( -caprolactone) / poly (glycolic acid) blended nanofibers for Tissue Engineering Applications

Polymer nanofibers exhibit properties that make them a favourable material for the development of tissue engineering scaffolds, filtration devices, sensors, and high strength lightweight materials. Electrospinning is a versatile method commonly used to manufacture polymer nanofibers. There are various parameters that can alter the electrospinning process, and varying one or more of these conditions will result in producing different nanofibrous webs. In this study, we prepared a blended nanofiber scaffold using synthetic polymers, Poly ("-caprolactone) and poly (glycolic acid), using the electrospinning method to prepare a material for tissue engineering. The aim of this study was to investigate the effect of material variables and process variables on the morphology of electrospun Poly ("- caprolactone) / poly (glycolic acid) nanofibrous structures. The morphology of the nanofibers produced was strongly influenced by parameters such as the flow rate of the polymer solution, the electrospinning voltage and the solution concentration. The results obtained indicate that the mean diameter of these nanofibers was uniformly electrospun and ranged from 80nm to 300 nm. The diameter was found to increase with solution concentration in a direct linear relationship. These findings contribute to determining the functional conditions to electrospin this biodegradable elastomeric polymer which has potential as a scaffold material for cardiac tissue engineering.

Keywords:

Nanofiber” , “ Electrospinning” , “Poly ( -caprolactone)” , “ Poly (glycolic acid)” , “Tissue engineering”