Nanosilica sulfamic acid catalysed synthesis of 2-phenylbenzoxazole Derivatives as heterogeneous catalyst

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

IRANCC20_227

تاریخ نمایه سازی: 28 اردیبهشت 1398

Abstract:

2-Arylbenzoxazoles are important heterocyclic motif widely found in bioactive molecules, pharmaceuticals and natural products [1]. 2-Substitued benzoxazoles are also fundamental scaffolds to construct novel ligands and materials. As such, four main strategies for their preparation have been reported such as transition metalcatalysed direct arylation of bezoxazoles with aryl halides; intermolecular cyclization of 2-aminophenol with aldehydes; intermolecular cyclization of halobenzanilides; and ring-opening-coupling-recyclization of benzoxazoles with aromatic aldehydes or benzoyl chloride [2-3]. Among them, acid-catalysed direct arylation of orthoaminophenol presents an economically attractive strategy to afford diverse 2- arylbenzoxazoles [4]. In this study we reported mild synthesis of 2-arylbenzoxazole derivatives in the presence of nanosilica sulfamic acid as heterogeneous catalysts (fig 1). We have demonstrated a nanosilica sulfamic acid-catalysed synthesis of benzoxazoles. The silica supported sulfamic acid catalysis promoted the condensation reaction in good to excellent yields with broad substrate scope, which provides a promising method for the synthesis of pharmacologically significant 2-aryl benzoxazole derivatives.

Authors

Seyed Hossein Banitaba

Department of Chemistry, Payame Noor University, P. O. BOX ۱۹۳۹۵-۳۶۹۷ Tehran, Iran

Hossein Kamali Ardekani

Department of Chemistry, Payame Noor University, P. O. BOX ۱۹۳۹۵-۳۶۹۷ Tehran, Iran