Synthesis of new phenyl(3-(trifluoromethyl)-4H-furo[3,4-b]indol-1- yl)methanone derivatives

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

IRANCC20_247

تاریخ نمایه سازی: 28 اردیبهشت 1398

Abstract:

The synthesis of biologically active organofluorine heterocyclics has received more attention in the medicinal chemistry and materials sciences [1]. Among these derivatives synthesis and development of new methods for preparation of CF3 containing heterocylic compounds have gained more attention, because of their physical and pharmaceutical properties and using in industry, medicinal and agriculture [2]. Our interest in fluorine chemistry and trifluoroacetimidoyl chloride reactions, and our attempt to synthesize bioactive organofluorine compounds led us to consider the reaction of trifluoroacetimidoyl chloride derivatives with 2-hydroxy-2- (1H-indol-3-yl)-1-phenylethan-1-one in acetonitrile and in the presence of NaH at ambient temperature for formation of phenyl(3-(trifluoromethyl)-4H-furo[3,4-b]indol-1- yl)methanone derivatives (Scheme 1). The structures of this products were proved by 1H-NMR, 13C-NMR, 19F-NMR and IR spectral data and elemental analysis. Reactions were clean and products were isolated by simple filtration.

Authors

Mahdiyeh Talebizadeh

Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran

Elham Kazemi

Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran

Ali Darehkordi

Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran

Mohammad Anary Abbasinejad

Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran