Mahdiyeh Talebizadeh - Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Elham Kazemi - Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Ali Darehkordi - Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Mohammad Anary Abbasinejad - Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran

The synthesis of biologically active organofluorine heterocyclics has received more attention in the medicinal chemistry and materials sciences [1]. Among these derivatives synthesis and development of new methods for preparation of CF3 containing heterocylic compounds have gained more attention, because of their physical and pharmaceutical properties and using in industry, medicinal and agriculture [2]. Our interest in fluorine chemistry and trifluoroacetimidoyl chloride reactions, and our attempt to synthesize bioactive organofluorine compounds led us to consider the reaction of trifluoroacetimidoyl chloride derivatives with 2-hydroxy-2- (1H-indol-3-yl)-1-phenylethan-1-one in acetonitrile and in the presence of NaH at ambient temperature for formation of phenyl(3-(trifluoromethyl)-4H-furo[3,4-b]indol-1- yl)methanone derivatives (Scheme 1). The structures of this products were proved by 1H-NMR, 13C-NMR, 19F-NMR and IR spectral data and elemental analysis. Reactions were clean and products were isolated by simple filtration.