An efficient synthesis of 1,8-dioxodecahydroacridine derivatives in the presence of glycerin

Substituted Acridines have been used as antimalarial for many years quite successfully and several of them have exhibited excellent results in chemotherapy of cancer. These derivatives are frequently used in industry, especially for the production of dyes [1-3]. The products identified by Perkin Elmer FT-IR spectrometer and 1H-NMR spectra on Bruker DRX- 300 MHZ NMR instrument. Aromatic aldehydes, aryl amines and dimedone were used in the synthesis of 1,8- dioxodecahydroacridine derivatives in glycerin media at room temperature (Scheme 1). High yields, simple and comfortable separate operation provided several special advantages this protocol.