The Study of the Interaction Between Silver Nanoparticles, DNA and Doxorubicin

Breast cancer, which affects an important percentage of human beings, occurs when abnormal cells grow out of control in one or both breasts. They can invade nearby tissues and form a mass, called a malignant tumor. Anthracyclines, particularly Doxorubicin are widely used antibiotics for medical treatments of breast cancer. Their bioactivity is due essentially to the ability to bind DNA and to the redox activity of the anthraquinone group. In this research, we have studied the interaction between silver nanoparticl, DNA and Doxorubicin using UV-Visible spectroscopy, fluorescence spectroscopy and the new solvation theory at 37 °C. Our new solvation model was used to reproduce the thermodynamic parameters of the interaction between anticancer drug of doxorubicin, DNA and silver nanoparticle. From this model, we have determined the binding constant and enthalpies of this interaction. The interaction of doxorubicin with varying silver nanoparticle concentration represented a set of two binding sites

Keywords:

Breast cancer , Doxorubicin , Silver nanoparticles , Thermodynamic parameters