Electrochemical investigation of acetaminophen/amlodipine interactions
Publish place: 20th Iranian Chemical Congress
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IRANCC20_393
تاریخ نمایه سازی: 28 اردیبهشت 1398
Abstract:
In this research, electrochemical oxidation of acetaminophen was investigated in the presence of amlodipine, an amine-containing drug. The electrochemical techniquesused include cyclic voltammetry and controlled-potential coulometry. The results indicated that N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen can react with amlodipine, based on the Michael addition reaction [1,2]. Corresponding product was synthesized in aqueous solutions by means of electrosynthesis, using a carbon electrode in an undivided cell. It was an environmentally friendly method because in which the application of toxic reagents has been eliminated. Synthesized product was identified by FT-IR, 1H-NMR and 13CNMR spectroscopies. The cyclic voltammograms were analyzed by digital simulation to measure thehomogeneous parameters for the suggested electrode mechanism [3]. The observed rate constant (kobs) for the reaction of electrochemically generated N-acetyl-p benzoquinn-imine with amlodipine were calculated in various pH (e.g. kobs=652±32.6 (M-1s-1)).
Authors
Fahime Tavakoli
Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran
Hassan Shayani-Jam
Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran
Mohammad Reza Yaftian
Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran
Masoumeh Parinejad
Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran