Survey reactivity of enaminones derivatives with pentafluoro(chloro)pyridine

Heterocyclic chemistry occupies an important place in organic chemistry research and ability to vary the properties of heterocyclic [1]. perhalogenated aromatic compounds are a class of heterocyclic that has drawn much attention due to their potentially in organic chemistry, as a building block for the synthesis of other heterocyclic, agrochemical and veterinary products [2], and possess biological and pharmaceutical activities [3]. Here in we tired the optimize reaction condition, while a one pot reaction of pentafluoro(chloro)pyridine and enaminones is achieved. The structures of all the compounds were confirmed by IR, 1H NMR 19F NMR and 13C NMR spectroscopy as well as elemental analysis Turning to our attention, synthesis of new substituted pyridine would be planned; proposed mechanism showed EA mechanism, initial attack occurs through carbon atom of enaminones attack to para position of perhalogenated heteroaromatic as electrophile, followed with Meisenheimer intermediates, and products can obtain in good yield.