Fluorescent determination of alprazolam via molecularly imprinted polymer embedded CdTe quantum dots sensor

Acting as a fluorescence sensing material, the molecularly imprinted polymer (MIP)[1] embedded CdTe quantum dots (QDs) [2] was constructed through sol-gel processfor highly efficient optosensing of alprazolam. The approach combined the merits of molecular imprinting technology and the fluorescent property of the CdTe QDs. Whenalprazolam is added to the medium that has a MIP@CdTe QDs composite, fluorescence quenching of this analyte is happened which is related to the concentration of the alprazolam. This fluorescence behavior is used for well testing of alprazolam with the detection limit and linear range of μM. Beside, the prepared sensors could well against the interferences from various biomolecules and be successfully used for the assay of alprazolam in human biological samples, exhibiting excellent specificity. On the other hand, in this work, microwave irradiation was utilized for the synthesis of water-soluble CdTe QDs. As it has been proven, that uniform nucleation and growth rate are critical for the synthesis of nanomaterials with high quality, the conventional hydrothermal synthetic route suffers from a main hindrance since it utilizes convective heating which can cause thermal gradient effects throughout the bulk solution [3]. The resulting composites were verified by Xray diffraction and Fourier transform infrared spectroscopy (FT-IR). The morphology of MIP-embedded QDs was observed by transmission electron microscopy (TEM).