Introducing an efficient method for preparation of 2,8-bis(methylthio)-5-propyl-5,10-dihydropyrido[2,3-d:6,5-d ]dipyrimidine-4,6-diol (L)

Hetero-fused pyrimidines are famous because of their interesting properties such as antiviral, antibacterial, anti-AIDS, and antinociceptive activities [1]. Folate metabolismhas long been known as a target for cancer chemotherapy because of the essential function of fused pyrimidine antifolates as antitumor agents [2]. A number of cardiocirculatory disorders were observed by atherothrombotic coronary artery diseases, such as unstable angina (UA), myocardial infarction (MI), or acute stroke associated with deep vein thrombosis (DVT), is one of the most major causes of death worldwide. The significance of fused pyrimidines as antiplatelet and antithrombotic drugs has been strongly built by clinical trials. Thus, additional investigation of pyrimidine chemistry looks to be worthwhile. In the present study, we report the synthesis of fused pyrimidines L with propyl side chain