Milad Namroudi - Department of Chemistry, Faculty of Science, Golestan University, Gorgan, Iran
Shabnam Hooshmand - Department of Chemistry, Faculty of Science, Golestan University, Gorgan, Iran
Ghasem Bahlakeh - Department of Chemistry, Faculty of Engineering, Golestan University, Gorgan, Iran

β-secretase (beta-amyloid converting enzyme 1[BACE1]) is involved in the first and rate-limiting step of β-amyloid (Aβ) peptides production, which leads to the pathogenesis of Alzheimer s disease(AD).Therefore, is an appropriate target for developing novel anti-Alzheimer drugs. In order to understand the structural characteristics correlated with the potency of BACE1 inhibitors, a Molecular Interaction Fields (MIF) based alignment independent three-dimensional quantitative structure-activity relationship (3D-QSAR) study was conducted. The predicted values of pIC50 are in good agreement with the experimental results of biological activity, indicating that the 3D-QSAR model can be select for further studies. The resulted model PLS analysis indicated that the compound activities were in good agreement with experimentally observed values (R2=0.73, Q2LOO=0.57 and R2 Pred=0.842).