Synthesis of novel amino and pyrrolyl acridine 1, 8-dione derivatives

A new series of amino substituted tetrahydroacridine 1, 8-diones were synthesized by multi-component reaction of dimedone, p-phenylene diamine and benzaldehyde derivatives. The synthesized amino acridines then were reacted with 2, 5-dimethoxy tetrahydrofurane in acetic acid to give pyrrolyl acridine 1, 8-diones [1], [2]. Acridine-1, 8-diones are important compounds due to their various pharmacological properties, such as cytotoxic, anticancer, antimicrobial, antifangal. Pyrrole nucleus is an essential structural motif in various groups of biologically active and natural molecules. (Fig.1)