Synthesis of titanomagnetite nanoparticles functionalized with sulfamic acid groups and applications for the synthesis of quinazolin derivatives

2,3-Dihydroquinazolin-4(1H)-ones are an essential class of heterocyclic compounds.In this research, an efficient and eco-friendly method has been developed for thesynthesis of quinazolin by silica- coated titanomagnetite nanoparticles functionalized with sulfamic acid groups and their applications as new catalyst . The catalyst can beseparated from the reaction mixture and used again as a catalyst. The compounds of quinazolines have many medicinal and biological properties. Their most importantPreparation of mono- and disubstituted 2,3-dihydroquinazoline (H1)-ones. To a solution of isatoic anhydride (1 mmol), 4-cl aniline(1 mmol) and aldehyde (1 mmol) under solvent‐free conditions. The reaction mixture was stirred at 100°C for an appropriate time. Once the reaction was completed, as monitored by TLC, the mixture was cooled to room temperature, diluted with 10 ml of ethanol and stirred for 10 min. Then, an external magnetic field was applied to separate the catalyst, and the remaining solution was evaporated. The precipitated solid product was recrystallized from ethanol to yield pure product.[1,2].