Fatemeh Rezaeemanesh - Department of Chemistry, Faculty of Science, shahrood University of Technology, shahrood, Iran
Mohammad bakherad - Department of Chemistry, Faculty of Science, shahrood University of Technology, shahrood, Iran
Hossein Nasr-Isfahani - Department of Chemistry, Faculty of Science, shahrood University of Technology, shahrood, Iran

Click chemistry offers a highly efficient technique for connecting two potential building blocks to other functional groups under mild conditions with high tolerance.Click reaction has been widely applied to the synthesis of macromolecules4 and functionalization of biomolecules [1]. 1,2,3-Triazole compounds have an important role not only in organic chemistry but also in medicinal chemistry, drug discovery, agrochemicals, and also as dyes due to their easy synthesis by click chemistry and interesting features as well as multiple biological activities [2]. The pyrimidine skeleton is an important class of nitrogen-containing heterocyclic compounds with a significant pharmacological efficiency including the anti-bacterial [3]. Considering the above subjects, and on the basis of our progressive endeavors in developing Cucatalyzed reactions of acetylenes leading to heterocyclic compounds of biological significance and environmental benign synthetic methodologies, herein we wish to report the synthesis of new derivatives of the 1,2,3-triazole-linked pyrimidine ring system via the copper-catalyzed click reactions