Functionalized nickel ferrite nanoparticles with phthalocianine-nickel complex as a nano catalyst for microwave assisted synthesis of 1,2,4,5-tetra aryl imidazoles

A novel, heterogeneous and magnetically recoverable phthalocyanine catalyst has been prepared by the coordinative anchoring the [PC-Ni(II)] complex on silica-coated magnetic nanoparticles (NiFe2O4@SiO2) through an amine functionality [1]. The heterogeneous catalyst was characterized by X-ray diffraction spectrum (XRD), scanning electron microscopy (FE-SEM), and Fourier transform spectrometry (FT-IR). Multi-substituted imidazoles, an important class of pharmaceutical compounds, exhibit a wide spectrum of biological activity such as anti-inflammatory, antiallergic, antibacterial, antitumor [2]. The prepared catalysts have been successfully used in the synthesis of 1,2,4,5-tetra aryl imidazoles from reaction of benzyl, aldehyde, amine derivatives and ammonium acetate as catalyst in the ethanol solvent under microwave conditions . The pure products were identified and characterized by physical and spectroscopic data such as; melting point, IR, and 1H NMR. The recycled NiFe2O4@SiO2PrA/PC-Ni(II) could be reused for five times without considerable loss of its catalytic activity and gave the corresponding product in high yields. The advantages of reported method are shorter reaction times, higher yields, a low amount of the catalyst, reusability of the catalyst and mild reaction conditions.

Keywords:

Magnetic nanoparticles , Phthalocyanine , 1 , 2 , 4 , 5-Tetra aryl imidazoles , Heterocycles , Synthesis.