A one-pot synthetic approach for construction of thiazolo[3,2- a]benzimidazole-linked quinoxaline scaffold via palladium-catalyzed reactions

Nitrogen heterocyclic compounds are the most abundant and integral scaffolds that occur ubiquitously in a variety of synthetic drugs, bio-active natural products, pharmaceuticals, and agrochemicals. Due to their broad applications, these compounds have long been a subject of great interest, and fundamental efforts have been made for the development of synthetic strategies that could lead to the discovery of new bioactive compounds in medicinal chemistry. [1]In this research work, a novel thiazolo[3,2-a]benzimidazole-linked quinoxaline system were synthesized by a multi-component reaction of 3-amine substituted 2-chloroquinoxalines, terminal alkynes and 1H-benzo[d]imidazole-2(3H)-thione in the presence of the palladium-copper catalyst. This one-pot process provided an efficient and successful approach for the construction of new thiazolo[3,2-a]benzimidazole-based quinoxaline scaffold with good-to-high yields. All the new synthesized compounds were characterized by the analytical spectral data