Green Synthesis of Silver Nanoparticles from Berberis Integerrima Extract and Their Antihyperglycemic Properties

This study investigates a comparison between antidiabetic effect of Berberis Integerrima (B. Integerrima) aqueous extract and its green synthesized silver nanoparticles in Streptozotocin-induced diabetic rats compared to diabetic rats that have been treated with chemical medicine Glibenclamide and we consider changes in their blood glucose and weights during treatment. Aqueous Extract of B. Integerrima were synthesized and it has been used for producing silver nano particles [1], [2]. The freeze-dried extract and green synthesized silver nanoparticles were characterized by SEM and uv-vis spectroscopy. 25 Rats weigh 200 - 250 grams divided into 5 groups: Normal group, Non-treated diabetic group, Diabetic group treated with B. Integerrima extract, Diabetic group treated with Silver Nanoparticles that are synthesized by B. Integerrima extract, and Diabetic group treated with Glibenclamide. Diabetes was induced by a single dose of Intraperitoneal injection of 50 streptozocin dissolved in saline serum, in diabetic groups.It has been seen that B. integerrima extract and Glibenclamide had approximately same effect on reducing blood glucose of diabetic rats, and the diabetic group of the rats that has been treated with silver nano particles synthsised with B. integerrima extract showed the most weight gaining during treatment.