Designing of Novel Multicomponent Reactions using 3-Formyl Chromone for the Synthesis of Functionalized Heterocyclic Skeletons

The synthesis of new chemical structures has always been a major challenge in the field of organic synthesis. In this context, multicomponent reactions (MCRs) are a powerful synthetic approach for generating complex molecules and are suitable for exploring substituent diversity. 3-Formyl chromones are used for the construction of different heterocyclic systems through reactions with binucleophiles. Meanwhile, chromonyl Meldrum’s acid is suitable substrate as starting material as a source of the chromone scaffold for its insertion into the structure of biologically active compounds. Here, different multicomponent reactions based on 3-formyl chromone and chromonyl Meldrum s acid present that could be used for the synthesis of different heterocyclic skeletons through the ring opening of chromone or without ring opening and formation of the functionalized chromone. For example, synthesis of chromone hydrazide and its reaction with malononitrile and primary amines in the presence of trimethylamine leading to fused pyrazolopyridines with chromone moiety. This presentation will focus on the synthesis of chromone derivatives and using them for the synthesis of functionalized heterocyclic skeletons