Determination of the association of ETS1 and WDFY4 gene polymorphisms with systemic lupus erythematosus in an Iranian population

Systemic Lupus Erythematosus (SLE) is a heterogeneous complex relapsing-remitting autoimmune disease. The role of genetics is obvious in predisposition of the disease. Several Single Nucleotide Polymorphisms (SNPs) in ETS1 and WDFY4 showed association with SLE in genome-wide association studies. The aim of this study was to examine the association of the SNPs in ETS1 and WDFY4 genes with SLE in an Iranian population. This study was performed on 280 patients that were not related to one another, and 281 healthy control subjects matched based on age, sex, and ethnicity, all of which were of Iranian origin. Rs10893872 and rs1128334 in the ETS1 gene, and rs877819 and rs707397 in the WDFY4 gene were genotyped using MGB TaqMan Allelic Discrimination Real-Time PCR. Our results showed no association in all mentioned SNPs with the susceptibility and clinical features of SLE in the Iranian population. The results were not consistent with genome-wide association studies performed on Asian and Caucasian populations.

Keywords:

Systemic lupus erythematosus , ETS1 , WDFY4