Relationship between FGFR2 gene rs2981582 polymorphism and the risk of breast cancer in the female population of Markazi province

Introduction: Breast cancer is the most common type of cancer and the leading cause of death in women worldwide, accounting for 23% of cancers and 400,000 deaths annually. Fibroblast Growth Factor 2 (FGFR2) receptor is a receptor of tyrosine kinase, which plays an important role in the growth and differentiation of cells. Several single nucleotide polymorphisms have been found in the intron 2 of the FGFR2 gene, which are associated with a high risk of breast cancer. The aim of this study was to investigate the relationship between rs2981582 polymorphism in the intron 2 of FGFR2 gene with breast cancer in the female population of Markazi province.Material and methods: 80 women with breast cancer and 80 healthy women (controls) were selected. Polymorphism has been analyzed for the study of association with breast cancer. The presence of this single-nucleotide polymorphism was determined by the RFLP-PCR technique. The results were analyzed by Chi-square test and significant values of P = 0.05 were considered.Results: Based on the results, there was a significant difference in the frequency of rs2981582 polymorphism in the FGFR2 gene between the control and patient groups (P = 0.000). In the patient group, the TT genotype was significantly associated with the risk of breast cancer (P = 0.001; OR = 3.566). On the other hand, allele C showed a protective role against the disease (P = 0.000).Conclusion: Our study showed a significant association between the rs2981582C/ T polymorphism and the risk of breast cancer, suggesting that this single-nucleotide polymorphism can be used as a biomarker to predict breast cancer.

Keywords:

Single nucleotide polymorphism , FGFR2 , RFLP-PCR , Breast cancer