Helicobacter pylori Stool Antigen Test Diagnostic and Predictive Values in Dyspepsia
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
SRCSRMED05_177
تاریخ نمایه سازی: 6 خرداد 1398
Abstract:
Background and Objectives: Iran, as a developing country, is experiencing high burdens of Helicobacter pylori (Hp)-associated non-communicable diseases. Hp stool antigen test (HpSA) is widely used as an inexpensive and feasible noninvasive method to diagnose Hp infection, instead of invasive approaches. The current study aimed at evaluating the diagnostic and predictive values of HpSA test for Hp infection in Iranian patients with dyspepsia. Methods: The current cross sectional study was performed on 100 patients with dyspepsia. Gastric mucosal specimens were taken, processed, and examined according to the standard protocols. Simultaneously, stool samples were obtained and sent to laboratory for further analyses. Hp stool antigen titers were assessed using enzyme-linked immunosorbent assay (ELISA) technique. Results: Stool antigen titers were not associated with gender (P-value=0.284), but correlated to age (r=0.213, P-value=0.034). Considering 0.385 as a cutoff point, the HpSA test had 80.4% sensitivity and 85.7% specificity. Conclusion: Based on cost-effectiveness of HpSA test, the current study findings corroborated the use of HpSA test to detect and follow-up patients with Hp infection, as an alternative method to detect Hp rather than invasive procedures.
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Authors
Fahimeh Safarnezhad Tameshkel
Gastrointestinal & Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran
Mohammad Hadi Karbalaie Niya
Dept. of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Zahedin Kheyri
Dept. of Internal Medicine, Amiralmomenin hospital, Arak University of Medical Sciences, Arak, Iran
Davood Azizi
Dept. of Pathology, Amiralmomenin hospital, Arak University of Medical Sciences, Arak, Iran